Esperion Therapeutics Presented Positive Top-Level Results for Phase 2 of Trials

Published on: 09 Aug, 2017

Esperion Therapeutics Inc (NASDAQ: ESPR) announced positive top-level results for Phase 2 of trials for triplet oral therapy with bempedoic acid, ezetimibe and atorvastatin.

The trials, which lasted six weeks, have yilded positive data as the LDL-C levels reportedly decreased 64% as a result of the triple therapy compared to the placebo treatment. Additionally, the therapy proved effective at a 48% reduction of a high-sensitivity C-reactive protein (hsCRP) which is an important marker of underlying inflammatory response associated with cardiovascular diseases. There were also no difference between the trail therapy and placebo treatment in terms of serious adverse events, muscle-related adverse events nor discontinuations due to muscle-related adverse events.

"Patients in this study experienced nearly a 100 mg/dL drop in their LDL-C levels on the combo plus atorvastatin. These highly positive study results of the combination therapy demonstrate very robust and remarkably consistent LDL-C lowering with what appears to be optimal safety and tolerability," said Tim M. Mayleben, president and chief executive officer of Esperion.

The company plans to continue testing multiple drug therapies in order to come to a most effective and flexible treatment plan for doctors and their patients. As a result of the extremely positive results of Phase 2, Esperion’s stock has risen about 24% on Tuesday.


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Nikita Medvedev



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